The objective of present study was to design and evaluate immediate release tablets of digoxin. There are various tablet formulations of digoxin available in the market. The purpose of the research is, to prepare digoxin immediate release tablet with low cost excipients as compared to marketed formulation and also to explore hydro-alcoholic wet granulation technique. In order to obtain the best product, nine different formulations were developed by using different filler, disintegrants and lubricants. The immediate release tablets were evaluated for weight variation, thickness, hardness, friability, disintegration time, content uniformity and in-vitro drug release. The in-vitro drug release was found to be faster in all formulations except F008 and F009 as compared to that of the reference product. The different physical properties and in-vitro release profile showed F008 and F009 as the best formulations comparable with the reference product and that F009 reproducible batch of F008.
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